The standard nasal spray pump volume per actuation is 0.1 ml (100 µl). This is the industry-standard delivery volume used by most pharmaceutical-grade metered-dose nasal spray devices, including those from Aptar, Nemera, and other major pump manufacturers.
Metered-dose nasal spray pumps use a mechanical piston system that delivers a precise, reproducible volume with each actuation — typically within ±5% of the rated output. Some specialty devices deliver different volumes:
- Standard metered-dose pumps: 0.1 ml (100 µl) — most common
- Low-volume pumps: 0.05 ml (50 µl) — for highly concentrated formulations
- High-volume pumps: 0.14 ml (140 µl) — less common, for dilute solutions
- Squeeze bottles: Variable (0.05–0.20 ml) — not recommended for precise dosing
For research compound dosing, always use a metered-dose pump and calibrate using the method above for accurate mcg-per-spray values.